Our companies solve hard but not impossible problems.
4
Funds raised
$50M
Current fund
$1-2M
Typical check
10%
Target ownership
Our Portfolio
Discover the companies shaping the future with Refactor.
Aerospace
Biotech
Miist develops orally inhaled therapeutics.
Rubedo is an anti-aging company hoping to extend health-span.
Verge uses ML and genomics to tackle neurodegenerative diseases.
Vitra is reimagining IVF.
Biorender is redefining how science is communicated.
Gencove's low-pass sequencing is the most efficient for genomic discovery.
Reel is scaling its vascularization technology to support therapeutics.
BBB trains AI models using biology.
Granza is advancing therapeutic delivery using precision shells.
YourChoice is developing the pill for men.
Phytoform edits crop genomes to activate novel traits.
Octant is building a novel drug discovery platform.
Adventris makes cancer vaccines.
Mythic is building smarter and safer anti-drug conjugates.
Loyal is giving our best friends (our dogs) more time with us.
Juvena develops therapeutics for tissue regeneration.
Parallel Bio uses immune organoids to design drugs.
Pilgrim develops battlefield-ready technology.
64x is transforming the future of cell and gene therapy manufacturing.
Shape is a next-gen RNA-targeting gene therapy company.
Critical Materials
Solugen manufactures chemicals using biology.
Knowde is bringing the chemical industry online.
Aether manufactures enzymes for novel products.
Intropic designs self-degradable products.
Hyfé turns plant waste into chemicals.
FYTO is building sustainable, novel nutrient-dense crops.
Checkerspot builds sustainable, algae-based physical materials.
Berkeley Yeast engineers brewer’s yeast to do incredible things.
Macro Oceans transforms kelp into chemicals.
Culture accelerates biomanufacturing.
Energy/Geo
Causal is building AI physics models to predict and control the weather.
Thalo helps reduce energy costs and emissions.
Pila is the simplest, smartest home backup battery.
Lumindt is building solid-state stationary storage systems.
Network Ocean builds underwater data centers.
Floodbase is a global parametric flood insurance solution.
Bedrock is innovating in battery chemistries.
General Galactic creates fossil-free fuels and chemicals.
Health
Picnic structures the world's medical data and makes it useful.
Curative is building a new employer health plan.
Headspace teaches millions in 200+ countries how to live mindfully.
AKASA is modernizing revenue cycle operations for healthcare.
Lucy’s aim is to eliminate smoking via effective nicotine products.
Biobot analyzes wastewater to analyze population threats.
Orchid helps couples have healthy babies.
PathAI is advancing medicine with intelligent pathology.
Kin creates functional beverages.
Vital is modern emergency department software.
Ophelia provides medication & support for quitting opioids.
Stealth
Graduates
Tempest is a digital recovery program and was acquired by Monument.
Clover is a Medicare Advantage company and went public ($CLOV).
Hero is a CRM app and was acquired by People.AI.
Coinbase is a cryptocurrency exchange and went public ($COIN).
Blockfolio is a crypto wallet and was acquired by FTX.
Enzyme is FDA compliance as a service and was acquired by Roivant ($ROIV).
FactoryFour builds automation software and was acquired by Xometry ($XMTR).
Uniform is a tele-health orthodontics company and was acquired by Impress Dental.
Betty Labs built Locker Room and was acquired by Spotify ($SPOT).
ANA is fighting COVID and was acquired by Neurobo ($NRBO).
Kip is a mental health company and was acquired by Modern Health.
Umbrella is a senior care marketplace and was acquired ($IAC).
Able helps providers get paid and was acquired by Health Catalyst ($HCAT).
Avail provides virtual surgery consults and was acquired by Mendaera.