Our companies solve hard but not impossible problems.
4
Funds raised
$50M
Current fund
$1-2M
Typical check
10%
Target ownership
Our Portfolio
Discover the companies shaping the future with Refactor.
Aerospace
Biotech
Loyal is giving our best friends (our dogs) more time with us.
Granza is advancing therapeutic delivery using precision shells.
Shape is a next-gen RNA-targeting gene therapy company.
Gencove's low-pass sequencing is the most efficient for genomic discovery.
BBB trains AI models using biology.
Phytoform edits crop genomes to activate novel traits.
Pilgrim develops battlefield-ready technology.
Verge uses ML and genomics to tackle neurodegenerative diseases.
Parallel Bio uses immune organoids to design drugs.
Adventris develops off-the-shelf cancer therapies.
Vitra is reimagining IVF.
Biorender is redefining how science is communicated.
Rubedo is an anti-aging company hoping to extend health-span.
64x is transforming the future of cell and gene therapy manufacturing.
Miist develops orally inhaled therapeutics.
YourChoice is developing the pill for men.
Octant is building a novel drug discovery platform.
Mythic is building smarter and safer anti-drug conjugates.
Reel is scaling its vascularization technology to support therapeutics.
Juvena develops therapeutics for tissue regeneration.
Critical Materials
Culture accelerates biomanufacturing.
Intropic designs self-degradable products.
Berkeley Yeast engineers brewer’s yeast to do incredible things.
Aether manufactures enzymes for novel products.
Knowde is bringing the chemical industry online.
Checkerspot builds sustainable, algae-based physical materials.
FYTO is building sustainable, novel nutrient-dense crops.
Macro Oceans transforms kelp into chemicals.
Solugen manufactures chemicals using biology.
Hyfé turns plant waste into chemicals.
Energy/Geo
Thalo helps reduce energy costs and emissions.
Floodbase is a global parametric flood insurance solution.
Hexium enriches isotopes for nuclear energy.
Pila is the simplest, smartest home backup battery.
Lumindt is building solid-state stationary storage systems.
Causal is building AI physics models to predict and control the weather.
General Galactic creates fossil-free fuels and chemicals.
Remedy is bringing land back online.
Network Ocean builds underwater data centers.
Health
Headspace teaches millions in 200+ countries how to live mindfully.
Lucy’s aim is to eliminate smoking via effective nicotine products.
Ophelia provides medication & support for quitting opioids.
Orchid helps couples have healthy babies.
AKASA is modernizing revenue cycle operations for healthcare.
Kin creates functional beverages.
Curative is building a new employer health plan.
Biobot analyzes wastewater to analyze population threats.
Vital is modern emergency department software.
PathAI is advancing medicine with intelligent pathology.
Picnic structures the world's medical data and makes it useful.
Stealth
Graduates
Coinbase is a cryptocurrency exchange and went public ($COIN).
Able helps providers get paid and was acquired by Health Catalyst ($HCAT).
Enzyme is FDA compliance as a service and was acquired by Roivant ($ROIV).
FactoryFour builds automation software and was acquired by Xometry ($XMTR).
Tempest is a digital recovery program and was acquired by Monument.
Betty Labs built Locker Room and was acquired by Spotify ($SPOT).
Avail provides virtual surgery consults and was acquired by Mendaera.
Clover is a Medicare Advantage company and went public ($CLOV).
Hero is a CRM app and was acquired by People.AI.
Uniform is a tele-health orthodontics company and was acquired by Impress Dental.
Kip is a mental health company and was acquired by Modern Health.
Umbrella is a senior care marketplace and was acquired ($IAC).
Blockfolio is a crypto wallet and was acquired by FTX.
ANA is fighting COVID and was acquired by Neurobo ($NRBO).