Our companies solve hard but not impossible problems.
4
Funds raised
$50M
Current fund
$1-2M
Typical check
10%
Target ownership
Our Portfolio
Discover the companies shaping the future with Refactor.
Aerospace
Biotech
64x is transforming the future of cell and gene therapy manufacturing.
BBB trains AI models using biology.
Mythic is building smarter and safer anti-drug conjugates.
Shape is a next-gen RNA-targeting gene therapy company.
Parallel Bio uses immune organoids to design drugs.
YourChoice is developing the pill for men.
Granza is advancing therapeutic delivery using precision shells.
Juvena develops therapeutics for tissue regeneration.
Pilgrim develops battlefield-ready technology.
Gencove's low-pass sequencing is the most efficient for genomic discovery.
Verge uses ML and genomics to tackle neurodegenerative diseases.
Vitra is reimagining IVF.
Miist develops orally inhaled therapeutics.
Loyal is giving our best friends (our dogs) more time with us.
Octant is building a novel drug discovery platform.
Adventris develops off-the-shelf cancer therapies.
Phytoform edits crop genomes to activate novel traits.
Reel is scaling its vascularization technology to support therapeutics.
Biorender is redefining how science is communicated.
Rubedo is an anti-aging company hoping to extend health-span.
Critical Materials
Macro Oceans transforms kelp into chemicals.
Hyfé turns plant waste into chemicals.
Intropic designs self-degradable products.
Aether manufactures enzymes for novel products.
Knowde is bringing the chemical industry online.
Berkeley Yeast engineers brewer’s yeast to do incredible things.
FYTO is building sustainable, novel nutrient-dense crops.
Culture accelerates biomanufacturing.
Solugen manufactures chemicals using biology.
Checkerspot builds sustainable, algae-based physical materials.
Energy/Geo
Hexium enriches isotopes for nuclear energy.
Remedy is bringing land back online.
General Galactic creates fossil-free fuels and chemicals.
Pila is the simplest, smartest home backup battery.
Causal is building AI physics models to predict and control the weather.
Lumindt is building solid-state stationary storage systems.
Thalo helps reduce energy costs and emissions.
Floodbase is a global parametric flood insurance solution.
Network Ocean builds underwater data centers.
Health
Headspace teaches millions in 200+ countries how to live mindfully.
Vital is modern emergency department software.
AKASA is modernizing revenue cycle operations for healthcare.
Picnic structures the world's medical data and makes it useful.
Curative is building a new employer health plan.
Lucy’s aim is to eliminate smoking via effective nicotine products.
Biobot analyzes wastewater to analyze population threats.
PathAI is advancing medicine with intelligent pathology.
Ophelia provides medication & support for quitting opioids.
Kin creates functional beverages.
Orchid helps couples have healthy babies.
Stealth
Graduates
Betty Labs built Locker Room and was acquired by Spotify ($SPOT).
Avail provides virtual surgery consults and was acquired by Mendaera.
Tempest is a digital recovery program and was acquired by Monument.
Kip is a mental health company and was acquired by Modern Health.
Clover is a Medicare Advantage company and went public ($CLOV).
Blockfolio is a crypto wallet and was acquired by FTX.
Coinbase is a cryptocurrency exchange and went public ($COIN).
Umbrella is a senior care marketplace and was acquired ($IAC).
Enzyme is FDA compliance as a service and was acquired by Roivant ($ROIV).
Hero is a CRM app and was acquired by People.AI.
Uniform is a tele-health orthodontics company and was acquired by Impress Dental.
FactoryFour builds automation software and was acquired by Xometry ($XMTR).
ANA is fighting COVID and was acquired by Neurobo ($NRBO).
Able helps providers get paid and was acquired by Health Catalyst ($HCAT).